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Research Group Hiltbrunner

Light Perception and Signalling in Plants

Institute of Biology II, Department of Molecular Plant Physiology, Faculty of Biology, University of Freiburg

Publications

  1. Hess, W.R. and Hiltbrunner, A. (2024).
    Take your sunscreen: plant photoreceptor systems in Serritaenia testaceovaginata.
    J. Exp. Bot. 75, 3206-3208. [PubMed] [doi: 10.1093/jxb/erae175]
  2. Vollmeister, E., Phokas, A., Meyberg, R., Böhm, C.V., Peter, M., Kohnert, E., Yuan, J., Grosche, C., Göttig, M., Ullrich, K.K., Perroud, P.-F., Hiltbrunner, A., Kreutz, C., Coates, J.C., and Rensing, S.A. (2024).
    A DELAY OF GERMINATION 1 (DOG1)-like protein regulates spore germination in the moss Physcomitrium patens.
    Plant J. 117, 909-923. [PubMed] [doi: 10.1111/tpj.16537]
  3. Klose, C. and Hiltbrunner, A. (2024).
    Measurement of Phytochrome B Thermal Reversion Rates In Vivo.
    Methods Mol. Biol. 2795, 85-93. [PubMed] [doi: 10.1007/978-1-0716-3814-9_9]
  4. Gao, M., Lu, Y., Geng, F., Klose, C., Staudt, A.-M., Huang, H., Nguyen, D., Lan, H., Lu, H., Mockler, T.C., Nusinow, D.A., Hiltbrunner, A., Schäfer, E., Wigge, P.A., and Jaeger, K.E. (2023).
    Phytochromes transmit photoperiod information via the evening complex in Brachypodium.
    Genome Biol. 24, 256. [PubMed] [doi: 10.1186/s13059-023-03082-w]
  5. Yuan, J., Xu, T., and Hiltbrunner, A. (2023).
    Phytochrome higher order mutants reveal a complex set of light responses in the moss Physcomitrium patens.
    New Phytol. 239, 1035-1050. [PubMed] [doi: 10.1111/nph.18977]
  6. Sorkin, M.L., Tzeng, S.-C., King, S., Romanowski, A., Kahle, N., Bindbeutel, R., Hiltbrunner, A., Yanovsky, M.J., Evans, B.S., and Nusinow, D.A. (2023).
    COLD REGULATED GENE 27 and 28 antagonize the transcriptional activity of the RVE8/LNK1/LNK2 circadian complex.
    Plant Physiol. 192, 2436-2456. [PubMed] [doi: 10.1093/plphys/kiad210]
  7. Yuan, J., Ott, T., and Hiltbrunner, A. (2023).
    Phytochromes and flowering: legumes do it another way.
    Trends Plant Sci., S1360-1385(23)00051-1. [PubMed] [doi: 10.1016/j.tplants.2023.02.004]
  8. Staudt, A.-M., Kretsch, T., and Hiltbrunner, A. (2023).
    EID1 promotes the response to canopy shade in Arabidopsis thaliana by repressing the action of phytochrome A.
    MicroPubl. Biol., 10.17912/micropub.biology.001015. [PubMed] [doi: 10.17912/micropub.biology.001015]
  9. Li, Z., Sheerin, D.J., von Roepenack-Lahaye, E., Stahl, M., and Hiltbrunner, A. (2022).
    The phytochrome interacting proteins ERF55 and ERF58 repress light-induced seed germination in Arabidopsis thaliana.
    Nat. Commun. 13, 1656. [PubMed] [doi: 10.1038/s41467-022-29315-3]
  10. Schwenk, P. and Hiltbrunner, A. (2022).
    Phytochrome A mediates the disassembly of processing bodies in far-red light.
    Front. Plant Sci. 13, 828529. [PubMed] [doi: 10.3389/fpls.2022.828529]
  11. Li, J. and Hiltbrunner, A. (2021).
    Is the Pr form of phytochrome biologically active in the nucleus?
    Mol. Plant 14, 535-537. [PubMed] [doi: 10.1016/j.molp.2021.03.002]
    corresponding authors: J.L., A.H.
  12. Schwenk, P., Sheerin, D.J., Ponnu, J., Staudt, A.-M., Lesch, K.L., Lichtenberg, E., Medzihradszky, K.F., Hoecker, U., Klement, E., Viczián, A., and Hiltbrunner, A. (2021).
    Uncovering a novel function of the CCR4-NOT complex in phytochrome A-mediated light signalling in plants.
    eLife 10, e63697. [PubMed] [doi: 10.7554/eLife.63697]
  13. Viczián, A., Klose, C., Hiltbrunner, A., and Nagy, F. (2021).
    Editorial: Plant phytochromes: from structure to signaling and beyond.
    Front. Plant Sci. 12, 811379. [PubMed] [doi: 10.3389/fpls.2021.811379]
  14. Murcia, G., Enderle, B., Hiltbrunner, A., and Casal, J.J. (2021).
    Phytochrome B and PCH1 protein dynamics store night temperature information.
    Plant J. 105, 22-33. [PubMed] [doi: 10.1111/tpj.15034]
  15. Kahle, N., Sheerin, D.J., Fischbach, P., Koch, L.-A., Schwenk, P., Lambert, D., Rodriguez, R., Kerner, K., Hoecker, U., Zurbriggen, M.D., and Hiltbrunner, A. (2020).
    COLD REGULATED 27 and 28 are targets of CONSTITUTIVELY PHOTOMORPHOGENIC 1 and negatively affect phytochrome B signalling.
    Plant J. 104, 1038-1053. [PubMed] [doi: 10.1111/tpj.14979]
  16. Xu, T., Yuan, J., and Hiltbrunner, A. (2020).
    PHYTOCHROME INTERACTING FACTORs in the moss Physcomitrella patens regulate light-controlled gene expression.
    Physiol. Plant. 169, 467-479. [PubMed] [doi: 10.1111/ppl.13140]
  17. Menon, C., Klose, C., and Hiltbrunner, A. (2020).
    Arabidopsis FHY1 and FHY1-LIKE are not required for phytochrome A signal transduction in the nucleus.
    Plant Commun. 1, 100007. [PubMed] [doi: 10.1016/j.xplc.2019.100007]
  18. Cheng, M.-C., Enderle, B., Kathare, P.K., Islam, R., Hiltbrunner, A., and Huq, E. (2020).
    PCH1 and PCHL directly interact with PIF1, promote its degradation, and inhibit its transcriptional function during photomorphogenesis.
    Mol. Plant 13, 499-514. [PubMed] [doi: 10.1016/j.molp.2020.02.003]
  19. Viczián, A., Ádám, , Staudt, A.-M., Lambert, D., Klement, E., Romero Montepaone, S., Hiltbrunner, A., Casal, J., Schäfer, E., Nagy, F., and Klose, C. (2020).
    Differential phosphorylation of the N-terminal extension regulates phytochrome B signaling.
    New Phytol. 225, 1635-1650. [PubMed] [doi: 10.1111/nph.16243]
    equally contributing first authors: A.V., E.A.
  20. Hiltbrunner, A. (2019).
    Shedding light on the evolution of light signalling.
    New Phytol. 224, 1412-1414. [PubMed] [doi: 10.1111/nph.16175]
  21. Xu, D., Marino, G., Klingl, A., Enderle, B., Monte, E., Kurth, J., Hiltbrunner, A., Leister, D., and Kleine, T. (2019).
    Extrachloroplastic PP7L functions in chloroplast development and abiotic stress tolerance.
    Plant Physiol. 180, 323-341. [PubMed] [doi: 10.1104/pp.19.00070]
  22. Hiltbrunner, A. (2019).
    Phytochromes: Methods and Protocols.
    2026. [doi: 10.1007/978-1-4939-9612-4]
  23. Enderle, B., Sheerin, D.J., Paik, I., Kathare, P.K., Schwenk, P., Klose, C., Ulbrich, M.H., Huq, E., and Hiltbrunner, A. (2017).
    PCH1 and PCHL promote photomorphogenesis in plants by controlling phytochrome B dark reversion.
    Nat. Commun. 8, 2221. [PubMed] [doi: 10.1038/s41467-017-02311-8]
  24. Xu, T. and Hiltbrunner, A. (2017).
    PHYTOCHROME INTERACTING FACTORs from Physcomitrella patens are active in Arabidopsis and complement the pif quadruple mutant.
    Plant Signal. Behav. 12, e1388975. [PubMed] [doi: 10.1080/15592324.2017.1388975]
  25. Angerer, V., Schwenk, P., Wallner, T., Kaever, V., Hiltbrunner, A., and Wilde, A. (2017).
    The protein Slr1143 is an active diguanylate cyclase in Synechocystis sp. PCC 6803 and interacts with the photoreceptor Cph2.
    Microbiology 163, 920-930. [PubMed] [doi: 10.1099/mic.0.000475]
  26. Possart, A., Xu, T., Paik, I., Hanke, S., Keim, S., Hermann, H.-M., Wolf, L., Hiß, M., Becker, C., Huq, E., Rensing, S.A., and Hiltbrunner, A. (2017).
    Characterization of phytochrome interacting factors from the moss Physcomitrella patens illustrates conservation of phytochrome signaling modules in land plants.
    Plant Cell 29, 310-330. [PubMed] [doi: 10.1105/tpc.16.00388]
    equally contributing first authors: A.P., T.X.; corresponding authors: A.P., A.H.
  27. Sheerin, D.J. and Hiltbrunner, A. (2017).
    Molecular mechanisms and ecological function of far-red light signalling.
    Plant Cell Environ. 11, 2509-2529. [PubMed] [doi: 10.1111/pce.12915]
  28. Menon, C., Sheerin, D.J., and Hiltbrunner, A. (2016).
    SPA proteins: SPAnning the gap between visible light and gene expression.
    Planta 244, 297-312. [PubMed] [doi: 10.1007/s00425-016-2509-3]
  29. Kirchenbauer, D., Viczián, A., Ádám, , Hegedus, Z., Klose, C., Leppert, M., Hiltbrunner, A., Kircher, S., Schäfer, E., and Nagy, F. (2016).
    Characterization of photomorphogenic responses and signaling cascades controlled by phytochrome-A expressed in different tissues.
    New Phytol. 211, 584-598. [PubMed] [doi: 10.1111/nph.13941]
    equally contributing first authors: D.K., A.V.
  30. Rensing, S.A., Sheerin, D.J., and Hiltbrunner, A. (2016).
    Phytochromes: More than meets the eye.
    Trends Plant Sci. 21, 543-546. [PubMed] [doi: 10.1016/j.tplants.2016.05.009]
    corresponding authors: S.A.R., A.H.
  31. Legris, M., Klose, C., Burgie, E.S., Rojas, C.C.R., Neme, M., Hiltbrunner, A., Wigge, P.A., Schäfer, E., Vierstra, R.D., and Casal, J.J. (2016).
    Phytochrome B integrates light and temperature signals in Arabidopsis.
    Science 354, 897-900. [PubMed] [doi: 10.1126/science.aaf5656]
  32. Hajdu, A., Ádám, , Sheerin, D.J., Dobos, O., Bernula, P., Hiltbrunner, A., Kozma-Bognár, L., and Nagy, F. (2015).
    High-level expression and phosphorylation of phytochrome B modulates flowering time in Arabidopsis.
    Plant J. 83, 794-805. [PubMed] [doi: 10.1111/tpj.12926]
    corresponding author: L.K.-B.
  33. Sheerin, D.J., Menon, C., zur Oven-Krockhaus, S., Enderle, B., Zhu, L., Johnen, P., Schleifenbaum, F., Stierhof, Y.-D., Huq, E., and Hiltbrunner, A. (2015).
    Light-activated phytochrome A and B interact with members of the SPA family to promote photomorphogenesis in Arabidopsis by reorganizing the COP1/SPA complex.
    Plant Cell 27, 189-201. [PubMed] [doi: 10.1105/tpc.114.134775]
    equally contributing first authors: D.J.S., C.M., S.z.O.-K.
  34. Possart, A., Fleck, C., and Hiltbrunner, A. (2014).
    Shedding (far-red) light on phytochrome mechanisms and responses in land plants.
    Plant Sci. 217-218, 36-46. [PubMed] [doi: 10.1016/j.plantsci.2013.11.013]
    corresponding authors: C.F., A.H.
  35. Possart, A. and Hiltbrunner, A. (2013).
    An evolutionarily conserved signaling mechanism mediates far-red light responses in land plants.
    Plant Cell 25, 102-114. [PubMed] [doi: 10.1105/tpc.112.104331]
  36. Pfeiffer, A., Nagel, M.-K., Popp, C., Wüst, F., Bindics, J., Viczián, A., Hiltbrunner, A., Nagy, F., Kunkel, T., and Schäfer, E. (2012).
    Interaction with plant transcription factors can mediate nuclear import of phytochrome B.
    Proc. Natl. Acad. Sci. U. S. A. 109, 5892-5897. [PubMed] [doi: 10.1073/pnas.1120764109]
    corresponding authors: A.P., E.S.
  37. Kami, C., Hersch, M., Trevisan, M., Genoud, T., Hiltbrunner, A., Bergmann, S., and Fankhauser, C. (2012).
    Nuclear phytochrome A signaling promotes phototropism in Arabidopsis.
    Plant Cell 24, 566-576. [PubMed] [doi: 10.1105/tpc.111.095083]
  38. Rausenberger, J., Tscheuschler, A., Nordmeier, W., Wüst, F., Timmer, J., Schäfer, E., Fleck, C., and Hiltbrunner, A. (2011).
    Photoconversion and nuclear trafficking cycles determine phytochrome A's response profile to far-red light.
    Cell 146, 813-825. [PubMed] [doi: 10.1016/j.cell.2011.07.023]
    corresponding authors: C.F., A.H.
  39. Infanger, S., Bischof, S., Hiltbrunner, A., Agne, B., Baginsky, S., and Kessler, F. (2011).
    The chloroplast import receptor Toc90 partially restores the accumulation of Toc159 client proteins in the Arabidopsis thaliana ppi2 mutant.
    Mol. Plant 4, 252-263. [PubMed] [doi: 10.1093/mp/ssq071]
    equally contributing first authors: S.I., S.B.
  40. Müller, R., Fernández, A.P., Hiltbrunner, A., Schäfer, E., and Kretsch, T. (2009).
    The histidine kinase-related domain of Arabidopsis phytochrome a controls the spectral sensitivity and the subcellular distribution of the photoreceptor.
    Plant Physiol. 150, 1297-1309. [PubMed] [doi: 10.1104/pp.109.135988]
  41. Pfeiffer, A., Kunkel, T., Hiltbrunner, A., Neuhaus, G., Wolf, I., Speth, V., Adam, E., Nagy, F., and Schäfer, E. (2009).
    A cell-free system for light-dependent nuclear import of phytochrome.
    Plant J. 57, 680-689. [PubMed] [doi: 10.1111/j.1365-313X.2008.03721.x]
  42. Genoud, T., Schweizer, F., Tscheuschler, A., Debrieux, D., Casal, J.J., Schäfer, E., Hiltbrunner, A., and Fankhauser, C. (2008).
    FHY1 mediates nuclear import of the light-activated phytochrome A photoreceptor.
    PLoS Genet. 4, e1000143. [PubMed] [doi: 10.1371/journal.pgen.1000143]
    corresponding authors: A.H., C.F.
  43. Trupkin, S.A., Debrieux, D., Hiltbrunner, A., Fankhauser, C., and Casal, J.J. (2007).
    The serine-rich N-terminal region of Arabidopsis phytochrome A is required for protein stability.
    Plant Mol. Biol. 63, 669-678. [PubMed] [doi: 10.1007/s11103-006-9115-x]
  44. Hiltbrunner, A., Tscheuschler, A., Viczián, A., Kunkel, T., Kircher, S., and Schäfer, E. (2006).
    FHY1 and FHL act together to mediate nuclear accumulation of the phytochrome A photoreceptor.
    Plant Cell Physiol. 47, 1023-1034. [PubMed] [doi: 10.1093/pcp/pcj087]
  45. Hiltbrunner, A., Viczián, A., Bury, E., Tscheuschler, A., Kircher, S., Tóth, R., Honsberger, A., Nagy, F., Fankhauser, C., and Schäfer, E. (2005).
    Nuclear accumulation of the phytochrome A photoreceptor requires FHY1.
    Curr. Biol. 15, 2125-2130. [PubMed] [doi: 10.1016/j.cub.2005.10.042]
  46. Hiltbrunner, A., Grünig, K., Alvarez-Huerta, M., Infanger, S., Bauer, J., and Kessler, F. (2004).
    AtToc90, a new GTP-binding component of the Arabidopsis chloroplast protein import machinery.
    Plant Mol. Biol. 54, 427-440. [PubMed] [doi: 10.1023/B:PLAN.0000036374.92546.51]
  47. Weibel, P., Hiltbrunner, A., Brand, L., and Kessler, F. (2003).
    Dimerization of Toc-GTPases at the chloroplast protein import machinery.
    J. Biol. Chem. 278, 37321-37329. [PubMed] [doi: 10.1074/jbc.M305946200]
  48. Smith, M.D., Hiltbrunner, A., Kessler, F., and Schnell, D.J. (2002).
    The targeting of the atToc159 preprotein receptor to the chloroplast outer membrane is mediated by its GTPase domain and is regulated by GTP.
    J. Cell Biol. 159, 833-843. [PubMed] [doi: 10.1083/jcb.200208017]
  49. Bauer, J., Hiltbrunner, A., Weibel, P., Vidi, P.-A., Alvarez-Huerta, M., Smith, M.D., Schnell, D.J., and Kessler, F. (2002).
    Essential role of the G-domain in targeting of the protein import receptor atToc159 to the chloroplast outer membrane.
    J. Cell Biol. 159, 845-854. [PubMed] [doi: 10.1083/jcb.200208018]
  50. Hiltbrunner, A., Bauer, J., Vidi, P.A., Infanger, S., Weibel, P., Hohwy, M., and Kessler, F. (2001).
    Targeting of an abundant cytosolic form of the protein import receptor at Toc159 to the outer chloroplast membrane.
    J. Cell Biol. 154, 309-316. [PubMed] [doi: 10.1083/jcb.200104022]
    equally contributing first authors: A.H., J.B.
  51. Bauer, J., Hiltbrunner, A., and Kessler, F. (2001).
    Molecular biology of chloroplast biogenesis: gene expression, protein import and intraorganellar sorting.
    Cell. Mol. Life Sci. 58, 420-433. [PubMed] [doi: 10.1007/PL00000867]
  52. Hiltbrunner, A., Bauer, J., Alvarez-Huerta, M., and Kessler, F. (2001).
    Protein translocon at the Arabidopsis outer chloroplast membrane.
    Biochem. Cell Biol. 79, 629-635. [PubMed] [doi: 10.1139/o01-145]
  53. Bauer, J., Chen, K., Hiltbrunner, A., Wehrli, E., Eugster, M., Schnell, D., and Kessler, F. (2000).
    The major protein import receptor of plastids is essential for chloroplast biogenesis.
    Nature 403, 203-207. [PubMed] [doi: 10.1038/35003214]
    equally contributing first authors: J.B., K.C, A.H.